Detalle de Empleo

Lab Technician at the epigenetic face of cancer metabolism Lab

We are looking for a Lab Technician who will perform the validation of a CRISPR-Cas9 knock out

Centre for Genomic Regulation
Barcelona
Media Jornada
Categoría : Calidad, producción e I+D Salario: € Experiencia : 1 

Descripción

Acerca de Centre for Genomic Regulation

The mission of the CRG is to discover and advance knowledge for the benefit of society, public health and economic prosperity. The CRG believes that the medicine of the future depends on the groundbreaking science of today. This requires an interdisciplinary scientific team focused on understanding the complexity of life from the genome to the cell to a whole organism and its interaction with the environment, offering an integrated view of genetic diseases. The CRG is a unique centre in Spain, based in an innovative organization research model. Group leaders at the CRG are recruited internationally and receive support from the centre to set up and run their groups. An external Scientific Advisory Board, made up of 15 world leaders in the different areas, evaluates them. The result of evaluations conditions the future of the CRG scientists, no matter whether they have open-ended or time-limited contracts. This ensures the mobility and the renewal of the workforce.

The Institute

The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed by an interdisciplinary, motivated and creative scientific team which is supported both by a flexible and efficient administration and by high-end and innovative technologies.

In November 2013, the Centre for Genomic Regulation (CRG) received the ‘HR Excellence in Research‘ Award from the European Commission. This is a recognition of the Institute’s commitment to developing an HR Strategy for Researchers, designed to bring the practices and procedures in line with the principles of the European Charter for Researchers and the Code of Conduct for the Recruitment of Researchers (Charter and Code).

Please, check out our Recruitment Policy

The role 

We are looking for a Lab Technician that will be responsible for performing the validation of a CRISPR-Cas9 knock out screen that we recently performed. The candidate will work together with a postdoctoral fellow for the first 2 months. During the 2 months, the candidate will be trained to perform the required experiments. After that time, the candidate is expected to actively communicate with her and the group leader to decide the experiments to be performed for the best development of the project.

About the lab

We are a team of researchers crazy about science, and funded by the European Council (ERC starting Grant 2019, EPICAMENTE).  We investigate the connection between metabolism and epigenetics, and its role in cancer development and progression.

The central role of metabolic rewiring during cancer progression is undeniable, but its direct impact on chromatin functions has been poorly investigated.

The team recently described that enzymes of central metabolism can localize on chromatin in cancer cells. However, their chromatin-associated roles remain mostly elusive. Therefore, the scope of our research is to dissect the role of enzymatic activities on chromatin, with a particular focus on cancer. To do so, we apply chemical biology and functional genomics approaches to unbiased chromatin reporters (REDS) for selected metabolic enzymes. We aim to identify the molecular networks defining the direct interplay between chromatin and cancer metabolism. Our research focuses on a brand-new area of cancer biology and has the potential to uncover novel chromatin-associated metabolic vulnerabilities. The breakthrough aspect of our investigation has been recognized by the European Research Council which, in 2019, awarded us with one of the prestigious ERC starting grant (https://erc.europa.eu/projects-figures/erc-funded-projects/results?search_api_views_fulltext=epicamente).

Whom would we like to hire? 

Professional experience 

Must Have 

  • You have at least one year of experience in cellular and molecular biology
  • You have proven experience in mammalian cell culture, Western Blot, IF and/or FACS

Desirable but not required/ Nice to have 

  • You have knowledge of CRISPR-Cas9 technology
  • You have experience in pooled genetic screens
  • You have knowledge of array screens
  • You have experience in cloning

Education and training 

  • You hold a degree in biomedical science or similar 

Languages 

  • You are fluent in English 

Competences 

  • You have good communication skills
  • You have a strong collaborative spirit
  • You are proactive and enthusiast 

The Offer – Working Conditions

  • Contract duration: 7 months part-time position (30 hours/week), covering of a maternity leave.
  • Estimated annual gross salary: Salary is commensurate with qualifications and consistent with our pay scales.
  • Target start date: 15 March, 2021. 

We provide a highly stimulating environment with state-of-the-art infrastructures, and unique professional career development opportunities. To check out our training and development portfolio, please visit our website in the training section.

We offer and promote a diverse and inclusive environment and welcomes applicants regardless of age, disability, gender, nationality, ethnicity, religion, sexual orientation or gender identity.

The CRG is committed to reconcile a work and family life of its employees and are offering extended vacation period and the possibility to benefit from flexible working hours.

Application Procedure

All applications must include:

  1. A motivation letter addressed to Dr. Sara Sdelci.
  2. A complete CV including contact details.
  3. Contact details of two referees.

All applications must be addressed to Dr. Sara Sdelci and be submitted online on the CRG Career site – http://www.crg.eu/en/content/careers/job-opportunities

Selection Process 

  • Pre-selection: The pre-selection process will be based on qualifications and expertise reflected on the candidates CVs. It will be merit-based.
  • Interview: Preselected candidates will be interviewed by the Hiring Manager of the position and a selection panel if required.
  • Offer Letter: Once the successful candidate is identified the Human Resources department will send a Job Offer, specifying the start day, salary, working conditions, among other important details.

Deadline: Please submit your application by 15th of March, 2021.

Please note that the position could be assigned before the deadline if a suitable candidate is found earlier.

Suggestions: The CRG believes in ongoing improvement and promotes a culture of feedback. This is one of the reasons we have in place, at your disposal as a candidate, a mechanism to gather your suggestions/complaints concerning your candidate experience in our recruitment processes. Your feedback really matters to us in our aim at creating a positive candidate journey. You can make a difference and help us improve by letting us know your suggestions through the following form.

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